MONOCLONAL ANTIBODIES AND NEW DRUGS

MONOCLONAL ANTIBODIES

1. Rituximab: Anti CD 20 / Anti B cell MAb. Human study underway for treatment of ANCA+ vasculitis.

2. Infliximab: Humanized Mouse Chimeric Anti TNFa (Rheumatoid Arthritis, Crohn’s)

3. Adalimumab: Fully humanized Anti TNFa (Rheumatoid Arthritis)

4. Etanercept: Recombinant TNF-receptor-Ig fusion protein Inhibit TNF-a (RA, JRA, Psoriasis).

5. Anakinra: Recombinant IL-1 receptor antagonist (IL-1Ra) : rheumatoid arthritis

6. OKT3: Anti-CD3 and T cell murine monoclonal antibody: Inhibit T cell function; induce T cell lymphopenia: treatment of cardiac and renal allograft rejection.

7. hOKT3 gamma-1: Humanized anti-CD3 monoclonal antibody: Eliminates auto-reactive T cells: Human study underway in Type I diabetes, psoriasis.

8. Daclizumab: Humanized anti-CD25 (IL-2R) monoclonal antibody, for graft versus host disease and UC (trial).

9. Omalizumab: Humanized anti-IgE monoclonal antibody, Human study underway for allergy (Hay fever, allergic rhinitis).


Will be updating

Dr.DV