Assessment of heart fatty acid-binding protein (H-FABP) identifies AMI less than 4hrs, with a sensitivity more than cardiac TrT, the lack of specificity in detecting AMI is obviously a major disadvantage of using H-FABP in this setting. H-FABP is also compared with several other biomarkers such as N-terminal pro-brain natriuretic peptide (NT-proBNP), d-dimer, high sensitivity C-reactive protein (hsCRP), myeloperoxidase (MPO), and matrix metalloproteinase-9 (MMP-9), which gave no additional information to cTnT regarding early sensitivity.
The traditional marker of early myocardial injury, myoglobin, is not compared with H-FABP in the study, but was reported as less reliable than H-FABP in a previous study
'Novel Biomarkers in Early Diagnosis of Acute Myocardial Infarction Compared with Cardiac Troponin T' by C.J. McCann et al., on page 2843
Medscape Article :
The Perfect Biomarker in Acute Coronary Syndrome: A Challenge for Diagnosis, Prognosis, and Treatment.
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