Thursday, January 15, 2009

Newer Medicines 2 : 11-20



11. Darunavir: Protease Inhibitor.


12. Dofetilide: Potassium Channel Blocker.

13. Enoximone: PDE IIIa inhibitor (Amrinone/Milrinone)

14. Eplerenone: Aldosterone antagonist.

15. Etomoxir: pFOX (Fatty acid oxidase) inhibitor.

16. Guanfacine: a selective alpha-2A-adrenoceptor agonist of CNS for ADHD.

17. HPV Vaccine (GARDASIL) against HPV 6, 11, 16 and 18.

18. Irinotecan: Topoisomerase 1 inhibitor, called CPT-11, a Camptothecin molecule, anti-leukemia agent, also useful in Colon carcinoma, producing a metabolite SN-38 which produces secretory diarrhoea manageable with Loperamide or Octreotide, and also myelosuppression especially with patients with deficient UGT1A1.

19. Istaroxime: Na+/K+ -ATPase inhibitor (E.g. Digoxin), FIRST DRUG to target LUSITROPY.

20. Ixabepilone: Microtubule inhibitor for monotherapy for metastatic breast cancer after treatment failure with other agents.

pgmeedoubts@gmail.com

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