Newer Medicines 2 : 21-30

21. Lapatinib : Kinase inhibitor used in metastatic breast cancer with HER2 overexpression.

22. Lenalidomide is an orally available thalidomide analog, exerting both anti-angiogenic and immunomodulatory/anti-inflammatory properties. Thrombocytopenia and neutropenia were the most frequently observed serious adverse events.

23. Lenalidomide: An IMID – Immunomodulatory derivative of Thalidomide.

24. Levosimendan: Calcium sensitizer.

25. Maprotiline: 2nd gen. antidepressant, with predominant NA reuptake inhibitor, little anticholinergic side effects, but may produce seizures.

26. Maraviroc – the first chemokine receptor antagonist, Entry Inhibitor for drug resistant HIV infection. Maraviroc blocks the main route of virus entry into uninfected cells—chemokine receptor 5 (CCR5).

27. Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). It is designed to replace natural IGF-1 in pediatric patients who are deficient, promoting normalized stature growth. Patients with severe primary IGF-1 deficiency (Primary IGFD) fail to produce adequate levels of IGF-1, due to disruption of the growth hormone (GH) pathway used to promote IGF-1 release (possible GH pathway disruptions include mutations in the GH receptor (GHR), post-GHR signaling pathway, and IGF-1 gene defects) and is specifically indicated for the long-term treatment of growth failure in pediatric patients with Primary IGFD or with GH gene deletion who have developed neutralizing antibodies to GH. It is not indicated to treat Secondary IGFD resulting from GH deficiency, malnutrition, hypothyroidism or other causes; it is not a substitute for GH therapy.

28. Modafinil: for patients with narcolepsy, sleep apnea, and shift work sleep disorder.

29. Natalizumab: recombinant humanized IgG4k monoclonal antibody produced in murine myeloma cells and is indicated for the treatment of patients with relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations, 300 mg IV infusion every four weeks.

30. Nesiritide: Recombinant BNP.


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