Differential Diagnosis of PANCYTOPENIA

Differential Diagnosis of PANCYTOPENIA
AIIMS November 2007, Medicine

Pancytopenia with Hypocellular Bone Marrow 

Acquired aplastic anemia

Constitutional aplastic anemia (Fanconi's anemia, dyskeratosis congenita)

Some myelodysplasia

Rare aleukemic leukemia (AML)

Some acute lymphoid leukemia

Some lymphomas of bone marrow

Pancytopenia with Cellular Bone Marrow 

Primary bone marrow diseases

  Myelodysplasia

  Paroxysmal nocturnal hemoglobinuria

  Myelofibrosis

  Some aleukemic leukemia

  Myelophthisis

  Bone marrow lymphoma

  Hairy cell leukemia

Secondary to systemic diseases

  Systemic lupus erythematosus

  Hypersplenism

  B₁₂, folate deficiency

  Overwhelming infection

  Alcohol

  Brucellosis

  Sarcoidosis

  Tuberculosis

  Leishmaniasis

Hypocellular Bone Marrow ± Cytopenia 

Q fever

Legionnaires' disease

Anorexia nervosa, starvation

Mycobacteria

pgmee notes by dv.