Hepatic Zonal Necrosis

TYPES OF HEPATIC ZONAL NECROSIS

I) Centilobular / Centrizonal Necrosis -

    a) Cardiac failure / Shock.

    b) CCl4 - Carbon Tetra Chloride.

    c) Chloroform Toxicity.

    d) Viral Hepatitis.

    e) Halothane Hepatitis (~1/35,000)

II) Peripheral Zonal Necrosis --> Necrosis around portal tracts.

     a) Eclampsia.(PIH)

     b) Phosphorus Poisoning.

III) Mid-zonal Necrosis --- RARE

       Seen in Yellow Fever.